Description
LL-37 is also known as Human Cathelicidin Antimicrobial Peptide (CAMP) and consists of 37 amino acids. (1) It belongs to the group of antimicrobial peptides (AMPs). It is derived from the C-terminal of Cathelicidin, which is a larger protein and is produced naturally in the human body. It is expressed by various tissues and bone marrow cells such as neutrophils, keratinocytes, myelocytes, natural killer cells, etc. The main function of LL-37 is the modulation of the immune system, through which it helps the body in fighting off various harmful microorganisms in the body.It is important to note that LL-37 specifically targets microorganisms that have otherwise achieved resistance to conventional antibiotics and are harder to treat. Therefore, it is a special peptide that targets antimicrobial resistance.
Since LL-37 is primarily an antimicrobial peptide, it can be used to fight off stubborn bacterial infections that are otherwise resistant to common antibiotics. It can also be used in chronic inflammatory autoimmune diseases such as psoriasis to fight off complications like psoriatic lesions, which may hinder everyday activities. LL-37 has proven to be effective against cancer cells as well. Therefore it can be used in the treatment of various types of cancer, which will eventually improve the prognosis of the disease. For patients who are at risk of developing cardio-pulmonary infections, LL-37 can be a useful peptide because of its anti-microbial and anti-inflammatory properties. LL-37 can also be used by people who may have suffered an injury and are looking to promote wound healing.
General suggestions are to start with 100 mcg per day. 100 mcg vial of LL-37 can be safely administered in a day for up to a maximum of 3 months. To observe benefits, it should be taken for at least one month. The dosing can also be increased gradually once the peptide has been introduced into the body. After one cycle, a break of approximately 2-4 weeks must be given before starting another cycle for the body to regenerate equilibrium. To obtain quicker benefits, stacking of LL-37 is often recommended. LL-37 is mostly stacked with TB-500, which is a regenerative peptide that enhances tissue healing and employs anti-inflammatory properties. It can also be paired with vitamin D, which is thought to have synergistic benefits on the working of LL-37.
