Amlodipine is used in the management of hypertension and coronary artery disease in people with either stable angina (where chest pain occurs mostly after physical or emotional stress) or vasospastic angina (where it occurs in cycles) and without heart failure. It can be used as either monotherapy or combination therapy for the management of hypertension or coronary artery disease. Amlodipine can be administered to adults and children 6–17 years of age. Calcium channel blockers, including amlodipine, may provide greater protection against stroke than beta blockers. Evidence from 2 meta-analysis have reported no significant difference between calcium channel blockers, Ace inhibitors, diuretics angiotensin receptor blockers in stroke protection while one 2015 meta-analysis has suggested that calcium channel blockers offer greatest protection against stroke than other classes of antihypertensive.